SINCE World War II, medical science has progressed with a stage where competitive medications are for sale to treat precisely the same ailment in different people. It’s not nearly brands (the industry trade issue) but generic drugs (the industry scientific issue). Within this report, we shall look at the various factors that decide picking a a selected drug.
Safety: The following sub-criteria has to be considered under the criterion of safety:
* Acute therapeutic index: When the patient’s condition is acute, how effective can be a particular drug regardless of whether it’s got certain side-effects as long as the acuteness in the condition is lowered? Example: narcotic pain-killers are amazing in healing pain but come with the potential side-effect of addiction.
* Long-term safety: medicine directory may be safe in short-term treatment, but how safe it’s in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but could have undesirable effects in case of prolonged use.
* Drug-drug interaction risk: Medicine is chemicals, and several chemicals respond to create a different chemical, that have an effect which could harm the individual or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.
Drug-drug interaction risk is of two types:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, outside of the other, have certain effects one or maybe more body processes (e.g., metabolism) that affects the performance in the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) is determined by for the metabolism. This will cause an increase in the side-effects of Lexapro.
· Pharmacodynamic: Here, 2 or more drugs actually produce the same influence on precisely the same organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects for example drowsiness and fatigue. Darvocet-N also acts similarly for the brain. Thus, the side-effects of both the prescription medication is more intense.
Tolerability: A medicine may be effective but not tolerable by all patients. Example: Allergies to particular drugs in most people. Short-term and long-term tolerability must be taken into account. Efficacy: A medicine isn’t equally efficient at all patients. As an example, some patients with depression or panic disorders experience respite from escitalopram, but there are numerous who don’t, who therefore must be prescribed some other anti-depressant. The speed of oncoming of therapeutic action is a the answer to be looked at too.
Cost: Cost does not always mean the expense of purchase of a specific medicine alone. It must also cover the expense of management of a complication which could arise while using some other drug. Example: In a individual that insists on taking alcohol yet needs to be treated for depression is generally administered an SSRI drug since these drugs don’t potentiate the end results of alcohol, whereas another gang of anti-depressants (for example tricyclics) can cause a new problem in such patients, which could require a various and expensive treatment. Therefore, it’s better to prescribe the more expensive escitalopram rather than a cheaper tricyclic such patients.
Simple treatment: The easiest mode of administration is preferred. If you have a choice between an injection and oral administration, the second is preferred when the efficacy of both the modes is comparable. Or, local application is chosen over the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are an important factor to make a decision simple treatment.
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