Selective androgen receptor modulators (SARMs) differentially bind to androgen receptors determined by each SARM’s chemical structure. Consequently, SARMs cause anabolic cellular activity while avoiding most of the negative effects of available today anabolic steroids. SARMs happen to be studied in the treatment of cancer of the breast and cachexia and possess also been utilized as performance-enhancing agents. Here, we evaluate and summarize the present literature on SARMs.
Aim
To provide the setting, mechanisms, current and potential clinical applications, along with risks and benefits of SARMs.
Methods
A literature review was performed in MEDLINE with all the terms selective androgen receptor modulator, hypogonadism, cachexia, cancer of the breast, benign prostatic hyperplasia, libido, and lean muscle mass. Both preliminary research and studies were included.
Main Outcome Measure
To accomplish a review of peer-reviewed literature.
Results
Though there are presently no U.S. Food and Drug Agency-approved indications for SARMs, investigators are going through the potential uses of these compounds. Research has focused on the pharmacokinetics and pharmacodynamics of those agents, demonstrating good availability which has a paucity of drug interactions. Early studies have demonstrated potential uses of SARMs inside the treatment of cancer-related cachexia, benign prostatic hyperplasia (BPH), hypogonadism, and cancer of the breast, with good success.
Conclusion
SARMs have several possible clinical applications, with promise for that safe use within the treating cachexia, BPH, hypogonadism, breast cancer, and prostate cancer.
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