SINCE Wwii, medical science has progressed with a stage where competitive medications are available to treat the identical ailment in numerous people. It’s not almost brands (the trade issue) but generic drugs (the scientific issue). Within this report, we shall go through the various factors that decide the selection of a selected drug.
Safety: The next sub-criteria have to be considered beneath the criterion of safety:
* Acute therapeutic index: In the event the patient’s condition is acute, how effective is a particular drug regardless of whether it has certain side-effects so long as the acuteness in the condition is lowered? Example: narcotic pain-killers work well in healing pain but come with the possibility side-effect of addiction.
* Long-term safety: medication directory might be safe in short-term treatment, but how safe it is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but sometimes have undesirable effects in case there is prolonged use.
* Drug-drug interaction risk: Medicine is chemicals, and a lot of chemicals reply to develop a different chemical, which has an effect that will harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to make a new condition that warrants separate treatment.
Drug-drug interaction risk is of 2 types:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, separate from one another, have certain effects using one or maybe more body processes (e.g., metabolism) that affects the performance in the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends upon because of its metabolism. This causes a boost in the side-effects of Lexapro.
· Pharmacodynamic: Here, two or more drugs actually create the same effect on the identical organ, thus improving the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of both the medicine is more serious.
Tolerability: A medicine might be effective but not tolerable by all patients. Example: Allergies to specific drugs in some people. Short-term and long-term tolerability should be considered. Efficacy: A medicine isn’t equally good at all patients. As an example, some patients with depression or anxiety attacks experience respite from escitalopram, but there are several that do not, who therefore should be prescribed an alternative anti-depressant. The pace of onset of therapeutic action is a crucial factor to be looked at too.
Cost: Cost does not always mean the cost of acquiring a certain medicine alone. It must also cover the cost of management of a complication that will arise while using an alternative drug. Example: In the person who insists on taking alcohol and yet should be treated for depression is normally administered an SSRI drug because these drugs don’t potentiate the consequences of alcohol, whereas another gang of anti-depressants (including tricyclics) could cause a fresh condition in such patients, which may need a different and expensive treatment. Therefore, it’s better to prescribe the more expensive escitalopram rather than cheaper tricyclic such patients.
Simple treatment: Most effective mode of administration is preferred. If you have an option between a shot and oral administration, rogues is preferred if the efficacy of both the modes is comparable. Or, local application is chosen over the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are key point to make a decision simple treatment.
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