SINCE World war 2, medical science has progressed to a stage where competitive medications are available to treat the same ailment in different people. It’s not nearly brands (the industry trade issue) but generic drugs (the industry scientific issue). In this report, we shall glance at the various factors that decide selecting a certain drug.
Safety: The following sub-criteria should be considered under the criterion of safety:
* Acute therapeutic index: In the event the patient’s condition is acute, how effective is often a particular drug even when they have certain side-effects so long as the acuteness of the condition is lowered? Example: narcotic pain-killers are very effective in healing pain but have the potential side-effect of addiction.
* Long-term safety: medication could be safe in short-term treatment, but wait, how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but could have undesirable effects in the event of prolonged use.
* Drug-drug interaction risk: Medicines are chemicals, and a lot of chemicals reply to produce a different chemical, which has an effect which could harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.
Drug-drug interaction risk is of two types:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, independent of one another, have certain effects one or even more body processes (e.g., metabolism) that affects the performance of the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is determined by due to the metabolism. This causes more the side-effects of Lexapro.
· Pharmacodynamic: Here, 2 or more drugs actually generate the same relation to the same organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of the medicines are more serious.
Tolerability: A medicine could be effective however, not tolerable by all patients. Example: Allergies to certain drugs in a few people. Short-term and long-term tolerability must be taken into consideration. Efficacy: A medicine is just not equally efficient at all patients. As an example, some patients with depression or anxiety disorders experience reduced escitalopram, but there are several who don’t, who therefore must be prescribed another anti-depressant. The pace of onset of therapeutic action is an important the answer to be regarded as too.
Cost: Cost doesn’t imply the expense of purchase of a specific medicine alone. It will also cover the expense of treating a complication which could arise while using another drug. Example: In the individual that insists on taking alcohol yet should be treated for depression is usually administered an SSRI drug since these drugs don’t potentiate the consequences of alcohol, whereas another group of anti-depressants (including tricyclics) can cause a brand new problem in such patients, which may demand a different and expensive treatment. Therefore, it’s easier to prescribe the more costly escitalopram rather than a cheaper tricyclic in this patients.
Simplicity of treatment: Most effective mode of administration is preferred. If you have an option between an injection and oral administration, the latter is preferred when the efficacy of the modes can be compared. Or, local application is chosen over the oral route where possible; e.g., antibiotic treating eye infections. Dosage and frequency of administration too are an important factor to decide simple treatment.
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