SINCE World War II, medical science has progressed to a stage where competitive medications are available to treat precisely the same ailment in various people. This is not nearly brands (the trade issue) but generic drugs (the scientific issue). In this report, we shall glance at the various factors that decide selecting a selected drug.
Safety: The subsequent sub-criteria must be considered beneath the criterion of safety:
* Acute therapeutic index: If your patient’s condition is acute, how effective is often a particular drug even if it’s certain side-effects so long as the acuteness of the condition is lowered? Example: narcotic pain-killers are very effective in healing pain but come with the possibility side-effect of addiction.
* Long-term safety: directory could possibly be safe in short-term treatment, but how safe it can be in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in case of prolonged use.
* Drug-drug interaction risk: Medicine is chemicals, and several chemicals answer create a different chemical, which has an effect that will harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to make a new condition that warrants separate treatment.
Drug-drug interaction risk is of two kinds:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, independent of one another, have certain effects using one or more body processes (e.g., metabolism) that affects the performance of the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) depends upon for its metabolism. This makes an increase in the side-effects of Lexapro.
· Pharmacodynamic: Here, two or more drugs actually create the same effect on precisely the same organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects such as drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of both the medicine is more serious.
Tolerability: A medicine could possibly be effective however, not tolerable by all patients. Example: Allergies to specific drugs in certain people. Short-term and long-term tolerability must be considered. Efficacy: A medicine isn’t equally good at all patients. By way of example, some patients with depression or panic attacks experience relief from escitalopram, but there are several that do not, who therefore must be prescribed some other anti-depressant. The pace of onset of therapeutic action is a the answer to be looked at too.
Cost: Cost does not necessarily mean the cost of acquiring some medicine alone. It will also cover the cost of treating a complication that will arise from using some other drug. Example: In a individual who insists on taking alcohol but should be treated for depression is generally administered an SSRI drug since these drugs don’t potentiate the consequences of alcohol, whereas another gang of anti-depressants (such as tricyclics) may cause a brand new condition in such patients, which could demand a various and expensive treatment. Therefore, it’s safer to prescribe the more expensive escitalopram rather than a cheaper tricyclic such patients.
Simplicity of treatment: The simplest mode of administration is preferred. If you have a choice between a shot and oral administration, the latter is preferred if the efficacy of both the modes is comparable. Or, local application is chosen over the oral route where possible; e.g., antibiotic treating eye infections. Dosage and frequency of administration too are a key factor to determine simplicity of treatment.
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