SINCE World War II, medical science has progressed to a stage where competitive medications are available to treat the identical ailment in several people. This is not pretty much brands (which is a trade issue) but generic drugs (which is a scientific issue). Within this report, we shall glance at the various factors that decide selecting a particular drug.
Safety: The following sub-criteria has to be considered underneath the criterion of safety:
* Acute therapeutic index: If your patient’s condition is acute, how effective is really a particular drug even though it has certain side-effects provided that the acuteness of the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but feature the potential side-effect of addiction.
* Long-term safety: medicationdirectory.com may be safe in short-term treatment, but wait, how safe it can be in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in case of prolonged use.
* Drug-drug interaction risk: Medicines are chemicals, and a lot of chemicals reply to make a different chemical, which has an effect that could harm the individual or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.
Drug-drug interaction risk is of two types:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, outside of the other, have certain effects one or maybe more body processes (e.g., metabolism) that affects the performance of the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) is dependent upon because of its metabolism. This makes more the side-effects of Lexapro.
· Pharmacodynamic: Here, 2 or more drugs actually create the same influence on the identical organ, thus improving the total, added effect. Example: Lexapro has certain side-effects such as drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of both medicine is more serious.
Tolerability: A medicine may be effective and not tolerable by all patients. Example: Allergies to particular drugs in certain people. Short-term and long-term tolerability must be taken into consideration. Efficacy: A medicine isn’t equally effective in all patients. For instance, some patients with depression or anxiety attacks experience respite from escitalopram, but there are numerous who don’t, who therefore must be prescribed a different anti-depressant. The rate of start of therapeutic action is an important factor to be regarded too.
Cost: Cost does not necessarily mean the price tag on buying some medicine alone. It should also cover the price tag on treatment of a complication that could arise by using a different drug. Example: Inside a individual who insists on taking alcohol and yet has to be treated for depression is generally administered an SSRI drug because they drugs don’t potentiate the end results of alcohol, whereas another number of anti-depressants (such as tricyclics) could cause a brand new overuse injury in such patients, which may require a different and expensive treatment. Therefore, it’s easier to prescribe the more expensive escitalopram instead of a cheaper tricyclic such patients.
Simplicity of treatment: The easiest mode of administration is preferred. If you have an alternative between an injection and oral administration, the second is preferred if your efficacy of both modes is comparable. Or, local application is preferred to the oral route where possible; e.g., antibiotic treatment of eye infections. Dosage and frequency of administration too are an important factor to decide simplicity of treatment.
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