SINCE World War II, medical science has progressed to some stage where competitive medications are for sale to treat the same ailment in various people. This isn’t pretty much brands (the trade issue) but generic drugs (the scientific issue). On this report, we shall glance at the various factors that decide your selection of a specific drug.
Safety: The subsequent sub-criteria have to be considered under the criterion of safety:
* Acute therapeutic index: If the patient’s condition is acute, how effective is often a particular drug even when it has certain side-effects providing the acuteness in the condition is lowered? Example: narcotic pain-killers are very effective in healing pain but have the possible side-effect of addiction.
* Long-term safety: medicine could be safe in short-term treatment, but how safe it is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in the event of prolonged use.
* Drug-drug interaction risk: Drugs are chemicals, and several chemicals answer produce a different chemical, which has an effect that may harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to make a new condition that warrants separate treatment.
Drug-drug interaction risk is of 2 types:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, independent of one another, have certain effects on one or more body processes (e.g., metabolism) that affects the performance in the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) is dependent upon because of its metabolism. This causes a boost in the side-effects of Lexapro.
· Pharmacodynamic: Here, several drugs actually generate the same effect on the same organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects such as drowsiness and fatigue. Darvocet-N also acts similarly around the brain. Thus, the side-effects of the two medicine is more intense.
Tolerability: A medication could be effective but not tolerable by all patients. Example: Allergies to specific drugs in a few people. Short-term and long-term tolerability have to be taken into consideration. Efficacy: A medication is not equally effective in all patients. By way of example, some patients with depression or anxiety attacks experience reduced escitalopram, but there are many that do not, who therefore have to be prescribed a different anti-depressant. The speed of onset of therapeutic action is a crucial key to be looked at too.
Cost: Cost does not always mean the cost of purchase of a certain medicine alone. It must also cover the cost of management of a complication that may arise by using a different drug. Example: Within a person who insists on taking alcohol and yet should be treated for depression is normally administered an SSRI drug since these drugs don’t potentiate the consequences of alcohol, whereas another number of anti-depressants (such as tricyclics) might cause a brand new overuse injury in such patients, which will need a various and expensive treatment. Therefore, it’s better to prescribe the more expensive escitalopram as opposed to a cheaper tricyclic in these patients.
Simplicity of treatment: The best mode of administration is preferred. If you find a selection between a shot and oral administration, the second is preferred when the efficacy of the two modes is the identical. Or, local application is preferred to the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are a key factor to make a decision simplicity of treatment.
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