SINCE World War II, medical science has progressed to some stage where competitive medications are available to treat precisely the same ailment in various people. This is simply not almost brands (which is a trade issue) but generic drugs (which is a scientific issue). Within this report, we shall consider the various factors that decide your selection of a particular drug.
Safety: The next sub-criteria must be considered beneath the criterion of safety:
* Acute therapeutic index: When the patient’s condition is acute, how effective is really a particular drug regardless of whether it’s got certain side-effects so long as the acuteness in the condition is lowered? Example: narcotic pain-killers are amazing in healing pain but have the opportunity side-effect of addiction.
* Long-term safety: drug could be safe in short-term treatment, but exactly how safe it can be in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in the case of prolonged use.
* Drug-drug interaction risk: Medicine is chemicals, and many chemicals reply to make a different chemical, that have an effect that will harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.
Drug-drug interaction risk is of two sorts:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, outside of the other, have certain effects on one or higher body processes (e.g., metabolism) that affects the performance in the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is determined by because of its metabolism. This will cause an increase in the side-effects of Lexapro.
· Pharmacodynamic: Here, a couple of drugs actually generate the same influence on precisely the same organ, thus helping the total, added effect. Example: Lexapro has certain side-effects such as drowsiness and fatigue. Darvocet-N also acts similarly for the brain. Thus, the side-effects of both medicine is more intense.
Tolerability: A drug could be effective and not tolerable by all patients. Example: Allergies to a particular drugs in a few people. Short-term and long-term tolerability should be looked at. Efficacy: A drug is just not equally effective in all patients. As an example, some patients with depression or panic attacks experience relief from escitalopram, but there are lots of that do not, who therefore should be prescribed another anti-depressant. The rate of beginning of therapeutic action is an important key to be regarded as too.
Cost: Cost does not always mean the price of acquiring a particular medicine alone. It should also cover the price of treating a complication that will arise from utilizing another drug. Example: Inside a individual that insists on taking alcohol yet has to be treated for depression is often administered an SSRI drug because these drugs don’t potentiate the consequences of alcohol, whereas another gang of anti-depressants (such as tricyclics) could cause a fresh overuse injury in such patients, which may require a different and expensive treatment. Therefore, it’s better to prescribe the more costly escitalopram instead of a cheaper tricyclic in these patients.
Simplicity of treatment: The best mode of administration is preferred. When there is a choice between an injection and oral administration, rogues is preferred if the efficacy of both modes is comparable. Or, local application is chosen over the oral route where possible; e.g., antibiotic treating eye infections. Dosage and frequency of administration too are key point to choose simplicity of treatment.
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